Applications
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Animal
Animal
The interdependence between humans, animals and the environment are of particular importance today, with the dramatic emergence and spread of zoonotic diseases, food, water and soil contamination, and the degradation of resources and habitats. All these events have led to an increase of risk factors for functional diseases, burdening global health. Metabolomics represents a technical solution for a holistic, collaborative, and precise approach for the advancement of the One Health strategy.
Cells
Cells
Cell metabolomics is an emerging field that addresses fundamental biological questions and allows one to observe metabolic phenomena in cells. Cell metabolomics consists of four sequential steps: (a) sample preparation and extraction, (b) metabolic profiles of low-weight metabolites based on MS techniques, (c) pattern recognition approaches and bioinformatics data analysis, (d) metabolites identification resulting in putative biomarkers and molecular targets. The biomarkers are eventually placed in metabolic networks to provide insight on the cellular biochemical phenomena.
Clinical
Clinical
Clinical metabolomics is able to illustrate an instantaneous snapshot of an individual by revealing the compound variety and concentrations of the metabolome. The unique metabolomic fingerprints and the underlying perturbations of metabolic pathways at the pathophysiological state offers a comprehensive avenue to inquire potential indicators, the metabolic phenotype of various diseases, and ultimately help address precision medicine.
Metabolomics can be applied to improve human health, as well as its trends and impacts in metabolic and neurodegenerative diseases, cancer, longevity, the exposome, liquid biopsy development, and pharmaco-metabolomics. The identification of distinct metabolomic profiles will help in the discovery and improvement of clinical strategies to treat human disease.
In the tumor research, metabolomics can be employed to identify biomarkers for prediction, diagnosis, and prognosis. Chemotherapeutic effect evaluation and personalized medicine decision-making can also benefit from metabolomic analysis of patient biofluid or biopsy samples.
Microbiome
Microbiome
The human microbiome plays an important role in our health and its composition and functionality is influenced by a variety of factors such as nutrition, environmental and pharmaceutical exposures, stress, and lifestyle. Metabolomics can be applied to elucidate the link between the human microbiome and the metabolism of various cell types.
Nutrition
Nutrition
Understanding the paths of basic nutrients is of importance from both translational and clinical perspectives. Metabolites are key biological communication channels and represent a functional readout at the interface of different major influential factors that define health and disease. Metabolomics is the technology that enables holistic and systematic analyses of metabolites in a biological system. Hence, given its intrinsic functionality, its tight connection to metabolism and its high clinical actionability potential, metabolomics is a very appealing technology for nutrition science. The ultimate goal is to deliver a tailored and clinically relevant nutritional recommendations and interventions to achieve precision nutrition. Metabolomics applications can be used to identify bioactive molecules and personalize nutrition remodeling clinical nutrition practices in this Precision Medicine era.
Fermentation
Fermentation
Metabolomics mass spectrometry analysis can be used to study fermented samples to understand how different conditions alter the metabolism of the bacteria and yeast, crucial information about nutrient compounds, and product accumulation.
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